MicroRNAs in acute myocardial infarction: Evident value as novel biomarkers?
نویسندگان
چکیده
منابع مشابه
MicroRNAs in acute myocardial infarction: Evident value as novel biomarkers?
Traditional circulating biomarkers play a fundamental role in the diagnosis and prognosis of acute myocardial infarction (AMI). However, they have several limitations. microRNAs (miRs), a class of RNA molecules that do not encode proteins, function directly at the RNA level by inhibiting the translation of messenger RNAs. Due to their significant roles in disease development, they can be used a...
متن کاملCirculating microRNAs are promising novel biomarkers of acute myocardial infarction.
OBJECTIVE Recent studies have revealed that microRNAs (miRNAs) are involved in the regulation of cardiac development, physiologic, and pathologic processes via post-transcriptional control of gene expression. The stable circulating miRNAs offer unique opportunities for the early diagnosis of several diseases. In this study, we examined the circulating miR-133 and miR-328 levels from patients wi...
متن کاملMicroRNAs as novel myocardial biomarkers.
The search for new biomarkers of cardiovascular disease remains a large and growing enterprise. Biomarkers are used to identify the risk, presence, and/or severity of disease; to guide diagnostic and therapeutic interventions; and to provide clues to disease mechanisms and pathophysiological distinctions within clinically similar populations. Among cardiovascular biomarkers, those used for iden...
متن کاملMicroRNAs as Biomarkers for Myocardial Infarction
MicroRNAs (miRs) are short non-coding RNA molecules involved in post-transcriptional gene regulation by binding to the 3' untranslated region of a messenger RNA (mRNA), thereby inhibiting the translation or inducing mRNA destabilization. MiRs are generally considered to act as intracellular mediators essential for normal cardiac function, and their deregulated expression profiles have been asso...
متن کاملsome biomarkers in acute myocardial infarction
background: several changes in serum biochemical factors occur in acute myocardial infarction (ami). recently alterations in serum levels of homocysteine (hcy), sialic acid (sa) and high sensitive c-reactive protein (hs-crp) has been attended as risk factors and index for prediction. this study was aimed to show the alterations in these factors and their relationships in ami. methods: thirty fo...
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ژورنال
عنوان ژورنال: The Anatolian Journal of Cardiology
سال: 2018
ISSN: 2149-2263
DOI: 10.14744/anatoljcardiol.2017.8124